Manny and Lo
Starring Scarlett Johansson (age 10?), Aleksa Palladino, and Mary Kay Place
Written and Directed by Lisa Krueger
1996
Amanda and Laurel are pre and post pubescent orphan sisters on a 'Thelma and Louise' run from foster care. Circumstances dictate they settle down in a country house and now all they need is to find parents!
This youtube video is an audition tape of Johansson's from a year or two earlier. She's a very cute kid, and, as they say, an 'old soul'.